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Rounds/Nickel/Applied AI Engineer·#25528
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Healthcare·Pre-Seed·San Francisco, California

Applied AI Engineer

at Nickel — Healthcare
Location
San Francisco, California
Type
Full-Time
About Nickel
Nickel's mission is to add ten healthy years to your life — specifically to democratize billionaire-quality longevity care at employer-plan cost. The best doctors in the world spend extraordinary time with their patients, integrate aggressive diagnostics and longevity science into a tailored journey, and build the business model around the patient rather than insurance. Nickel is bringing that standard of care to everyone. The product architecture is unusual and technically ambitious: - Sovereign on-premise hardware: a GPU-equipped box that lives inside the physician's clinic. Patient data never leaves the practice. Sub-second local compute - Software stack: integrates with EHRs (Epic, Athena), wearables (Apple Watch, Samsung, Fitbit, Aura Ring), lab work, and imaging systems including Prenuvo full-body MRI - In-clinic camera and ambient voice: during appointments, the box captures body signals (skin flush, fatigue, posture) alongside voice — synthesizing multi-modal signals into a physician-facing recommendation - Human-in-the-loop AI: the AI generates concierge-medicine recommendations. The physician reviews and approves before anything reaches the patient. Nickel does not replace physicians; it 10x's their throughput - Marketplace layer: patients get concierge recommendations across a curated provider network (cryotherapy, red light therapy, nutrition, supplements, physical therapy, adjacent scans). Nickel monetizes the marketplace referrals The business dual-benefit: physicians can serve more patients at a higher standard of care. Patients get more services for the same spend. Nickel captures value on the marketplace referrals plus the hardware/software subscription. Stage and traction: - $30M pre-seed raise - Team of 20: ~10 hardware engineers in Shenzhen (China), plus stateside leadership from NVIDIA, Nike, NASA JPL, Samsung Health, plus ZS Associates - Aug 1, 2026 soft launch (internal / limited) - Nov 1, 2026 consumer launch (public) - Currently quasi-stealth
Website
Pre-Seed • 11 – 50
Stage & size
Healthcare
Industry
2025
Founded
About This Role

An applied AI engineer — explicitly not an AI researcher or frontier-model builder (the CTO owns that). This person understands the moving landscape of AI/ML capabilities and techniques, is fluent with open-weight / open-source models Nickel can run on its sovereign on-prem boxes, and builds the agents that interact with those models, the clinical data, and the medical protocols injected into the system. Every agent lives in a harness with heavy guardrails and eval functions so it behaves as intended — and because this is human-in-the-loop medical AI on PHI, everything the agent consumes or concludes (summaries/interpretations surfaced to physicians — never autonomous decisions) must be fully traceable.

A big part of the job is the practical craft of agents: agent drift detection (understanding how/why an agent diverges from its original purpose, monitoring it, then recovering, decommissioning, or redeploying), and the disciplined use of agentic code generators to build agents with guardrails, evals, unit/integration tests at every step — plus what the harness must provide for orchestration, logging, traceability, and drift detection. Prior experience doing exactly this is great; if not, they'll consider someone who can clearly get there given time and self-directed research. Like the architect, this is an end-to-end IC. They should also understand the data foundation — especially how the knowledge graph is built and navigated (which slice makes an agent more effective and surfaces correct vs. incorrect conclusions) — though a data-retrieval API abstracts the storage layer beneath them.

What You'll Own

  • Build agents that interact with open-weight/open-source models, clinical data, and injected medical protocols
  • The harness around them: guardrails, eval functions, orchestration, logging, traceability
  • Agent drift — monitoring, detection, recovery/decommission/redeploy
  • Disciplined agent-building with agentic code generators + unit/integration tests at each step
  • Effective knowledge-graph navigation to feed agents the right context

Requirements

  • Applied AI/ML engineer (not a researcher) — strong grasp of the current model/technique landscape
  • Fluent with open-weight / open-source models and running them locally
  • Real agent-building craft: guardrails, evals, harnesses, orchestration, logging
  • Agent drift detection + recovery/decommission/redeploy experience (strongly preferred)
  • Disciplined use of agentic code generators with tests at every step
  • Understands knowledge-graph construction/navigation and data retrieval
  • PHI/regulated traceability awareness for agent data access

Who Will Thrive Here

  • An applied-AI engineer who loves the practical craft of reliable, evaluable agents (not model research)
  • Comfortable with open-source models, harnesses, drift, and eval discipline
  • Cares about traceability and safety in a human-in-the-loop medical context
  • Self-directed IC who'll research and build what's needed
Job Details
Experience
5-10 Years
Salary
—
Equity
—
Visa Sponsorship
—
Employment Type
Full-Time
Work Arrangement
In office
Work Intensity
9-9-5
Benefits & Perks

No benefits listed yet.

Green Flags
Shipped production agents end-to-end with evals and guardrails (not demos)
Built or operated agent harnesses with orchestration, logging, observability
Hands-on drift detection / monitoring and recovery-redeploy work
Red Flags
AI researcher / frontier-model-trainer who hasn't shipped production agents
No eval / guardrail / traceability discipline — "just wire up an API"
Closed frontier-API-only; can't work with open-weight/local models

Candidate scorecard

· 6 criteria
Applied AI/ML engineer (not a researcher) with a strong grasp of the current model/technique landscape
Fluent with open-weight / open-source models and running them locally / on-prem
Real agent-building craft — harnesses, guardrails, eval functions, orchestration, logging
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