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Rounds/Keyframe Labs/GTM Engineer·#49503
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AI·Seed·San Francisco, CA

GTM Engineer

at Keyframe Labs — AI
Location
San Francisco, CA
Salary
$100,000 - $300,000
Type
Full-Time
TL;DR
  • Role: GTM Engineer
  • Experience: 2–4 years
  • Location: San Francisco, CA (in-office; at least one interview in person required)
  • Visa: US citizens and candidates eligible for transfer/renewal sponsorship (no long overseas waits)
About Keyframe Labs
Keyframe Labs is a seed-stage AI startup based in San Francisco, focused on building advanced agentic AI and computational chemistry solutions. The company operates from the Antler office in east SF and is led by a founding team with deep expertise in AI, engineering, and computational science. Keyframe Labs is actively hiring to expand its core technical team and is open to candidates who can work in-office in San Francisco.
Seed • 1 – 10
Stage & size
AI
Industry
2025
Founded
About This Role

Keyframe Labs is scaling its technical team to accelerate the development of agentic AI and computational chemistry products, requiring in-office engineers who can contribute to both product and research initiatives.

This role is hands-on and based in San Francisco, with a focus on building frontier-level harnesses for agentic AI use cases or conducting research at the LLM/harness optimization level. The primary spike is deep technical contribution to either agentic AI systems or computational chemistry modeling, depending on your background.

What You'll Own

  • Develop and optimize agentic AI harnesses for product or research use cases
  • Contribute to research on LLMs, harness optimization, or embedding semantic knowledge/context/graphs into agents
  • For computational chemists: apply quantum-level chemistry expertise (e.g., DFT, transition state modeling, thermodynamics, kinetics) to product development
  • Collaborate closely with founders and technical leaders in the SF office

Technical Requirements

  • Expertise in agentic AI systems, LLM research, or computational chemistry (quantum-level, e.g., DFT, transition modeling)
  • Recent PhD (last 4–5 years) in quantum chemistry or 3–4 years' experience at a chemistry/AI company preferred for computational chemist track

Execution and Ownership

  • Work in-office in San Francisco, collaborating directly with the founding team
  • Participate in at least one in-person interview as part of the hiring process

Background

  • PhD in quantum chemistry (last 4–5 years) or 3–4 years' experience at a chemistry/AI company for computational chemist track
  • Demonstrated experience building agentic AI harnesses or conducting LLM/harness optimization research

Location and Visa

  • Role is based in San Francisco, CA; in-office presence required
  • Visa sponsorship available for transfers/renewals (e.g., H-1B transfer), but not for long overseas waits; US-based candidates strongly preferred

Nice to Have

  • Graduated from a top-tier institution or worked under a professor known for quantum chemistry
  • Experience in both agentic AI and computational chemistry

Who Will Thrive Here Engineers and researchers who want to work on cutting-edge AI or computational chemistry in a collaborative, in-person environment, and who are motivated by deep technical challenges and close interaction with founders.

Job Details
Experience
2-4 Years
Salary
$100,000 - $300,000
Equity
1% - 2%
Visa Sponsorship
Yes
Employment Type
Full-Time
Work Arrangement
In office
Work Intensity
9-5-5
Benefits & Perks

No benefits listed yet.

Green Flags
Recent experience at top-tier institutions or companies focused on agentic AI or advanced AI research
Track record of deep technical contributions in agentic AI, LLMs, or harness optimization
Clear motivation to build for science or agentic AI, not just seeking a short-term role
Red Flags
Requires new US visa with a long overseas wait (e.g., 6+ months)
Unwilling or unable to work in-office in San Francisco
No evidence of hands-on experience with agentic AI, LLM research, or harness building

Candidate scorecard

· 6 criteria
2-4 years of relevant experience in a similar role
Ability and willingness to work full-time, in-office in San Francisco, CA
Eligible for US work authorization with no long overseas visa wait; visa transfers or renewals are acceptable
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